Do you prefer 100% natural fibres or is dead stock polyester/poly blends ok?

Hey y’all I have been making clothes for some friends who try to prioritize natural fibres and I keep coming across cute deadstock fabrics that are either poly blends or 100% polyester. We had a big convo about deadstock and now I’m just curious if you guys find wearing the polyester itself troubling or just the creation of polyester troubling. Would you avoid buying something with polyester even if it was second hand fabric/deadstock? Thanks!!